SUMO Protease 1

KBC SUMO Protease I – Highly Specific Protease for SUMO Tag Removal

KBC SUMO Protease I is a highly specific recombinant protease designed for the removal of SUMO tags from fusion proteins. The enzyme is based on Ulp1 protease derived from Saccharomyces cerevisiae and specifically recognizes the SUMO structure, enabling precise cleavage of the fusion protein and efficient separation of the SUMO tag from the target protein.

This protease is capable of recognizing and cleaving Smt3 as well as human SUMO proteins Hsumo1-3. The high specificity of KBC SUMO Protease I enables cleavage at the C-terminal end of the SUMO tag, allowing recovery of the target protein after tag removal. Therefore, the enzyme is suitable for recombinant protein expression and purification applications.

KBC SUMO Protease I contains a His-tag, allowing the protease to be conveniently separated from the target protein after the cleavage reaction when Ni-NTA-based purification systems are used. This feature facilitates SUMO tag removal and preparation of recombinant proteins for subsequent research applications.

KBC SUMO Protease I is a highly specific recombinant Ulp1 protease for efficient removal of SUMO tags from fusion proteins, suitable for recombinant protein expression and purification workflows