AneuQuick Extra Plus v2.2
Cat. No: KBC-110114AneuQuick™ Extra Plus v2.2
AneuQuick™ Extra Plus v2.2 is an advanced QF-PCR (Quantitative Fluorescent PCR) assay developed for the rapid and simultaneous detection of the most common fetal chromosomal aneuploidies, including chromosomes 13, 18, 21, X, and Y, together with the detection of the of the presence or absence of exon 7 of the SMN1and SMN2 genes for 5q Spinal Muscular Atrophy ( 5qSMA) screening.
The assay amplifies 35 carefully selected genetic markers in a single-tube multiplex PCR reaction, enabling accurate detection of the most common fetal chromosomal abnormalities—including Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), Patau syndrome (Trisomy 13), Turner syndrome (Monosomy X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX) and other sex chromosome aneuploidies—while assessing the SMN1/SMN2 status in the same workflow.
AneuQuick™ Extra Plus v2.2 designed for high-throughput molecular genetics laboratories and prenatal diagnostic center, AneuQuick™ Extra Plus v2.2 combines QF-PCR technology with 6 dye capillary electrophoresis to deliver fast, reliable and highly reproducible results.
Sample Compatibility
AneuQuick™ Extra Plus v2.2 is validated for use with DNA extracted from peripheral blood, amniotic fluid, chorionic villus samples (CVS), tissue specimens, cell-free DNA from amniotic fluid, and KBC DBC™ DNA Storage Cards. By combining an expanded STR panel, Segmental Duplication markers, and dedicated SMA markers, the kit provides a practical and efficient solution for molecular genetics laboratories and prenatal diagnostic centers seeking comprehensive genetic screening in a single assay.
| reaction | 100, 25, 50 |
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Key Features & Benefits
- Simultaneous detection of aneuploidies involving chromosomes 13, 18, 21, X, and Y, together with SMN1 exon 7 deletion/conversion
- Detects common chromosomal disorders including Down, Edwards, Patau, Turner, Klinefelter, Triple X, and other sex chromosome abnormalities
- Based on QF-PCR technology for rapid prenatal testing with a streamlined workflow
- Amplifies 35 genetic markers in a single-tube multiplex PCR reaction
- Includes three Segmental Duplication markers (7/X, 11/X, and 18/X) for improved assessment of X chromosome copy number and more confident detection of Turner syndrome
- Features five additional STR markers compared with AneuQuick™ Extra Plus v2.2 for enhanced chromosome coverage and result interpretation
- Enables simultaneous evaluation of SMN1 and SMN2, eliminating the need for a separate SMA screening assay
- Compatible with multiple prenatal and clinical DNA sample types
- Optimized for 6-dye fragment analysis
- Delivers reliable, reproducible performance for molecular genetics, prenatal diagnosis, and research laboratories
AneuQuick™ Extra Plus v2.2 incorporates 35 genetic markers distributed across chromosomes 13, 18, 21, X, and Y. The panel combines highly informative Short Tandem Repeat STR markers, Segmental Duplication markers, and dedicated SMN1/SMN2 markers, providing comprehensive analysis of both chromosomal aneuploidies and SMA-associated variants within a single assay.
Figure 1. Distribution of AneuQuick™ Extra Plus v2.2 markers with the KBC600™ Size Standard.
Compared with other products in the AneuQuick™ family, the Extra Plus version contains additional SD markers including,10/18,18/X,6/21,18/1,13/1and21/2 these markers reduce likelihood of inconclusive or misleading results while enhancing the detection of sex chromosome abnormalities, particularly Monosomy X (Turner syndrome). The panel also includes the proprietary DX-TATC 13.3 marker, providing greater discriminatory power than many comparable commercial assays.
In addition, dedicated SMN1 and SMN2 markers enable simultaneous assessment of SMN1 exon 7 deletion or conversion, extending the clinical value of the assay beyond conventional QF-PCR aneuploidy testing.
Comparison Table
The AneuQuick™ product family offers a range of QF-PCR kits designed for rapid prenatal aneuploidy screening and tailored to different laboratory requirements. Depending on the application, laboratories can choose from standard panels, expanded marker panels, or advanced kits with integrated SMA detection.
The comparison table below summarizes the key specifications of each AneuQuick™ kit, including marker count, chromosome coverage, Segmental Duplication markers, SMA detection capability, fluorescence chemistry, and instrument compatibility, making it easier to identify the most suitable solution for your workflow.
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Feature |
AneuQuick v4.2 | AneuQuick Plus v2.2 | AneuQuick Extra v2.2 | AneuQuick Max v2.2 | AneuQuick Extra Plus v2.2 | AneuQuick Max Plus v2.2 |
| Total Markers | 27 | 29 | 33 | 33 | 35 | 35 |
| X markers | 7 | 7 | 8 | 8 | 8 | 8 |
| X/Y markers | 2 | 2 | 2 | 2 | 2 | 2 |
| Chr. 21 markers | 6 | 6 | 8 | 8 | 8 | 8 |
| Chr. 18 markers | 5 | 5 | 8 | 7 | 8 | 7 |
| Chr. 13 markers | 5 | 5 | 6 | 7 | 6 | 7 |
| Segmental Duplication | 2 | 2 | 8 | 3 | 8 | 3 |
| SMA Detection | No | ✓ | No | No | ✓ | ✓ |
| 5- or 6-dye system | 5 | 5 | 6 | 6 | 6 | 6 |
| Single tube multiplex | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Compatible with | Spectrum Compact CE from Promega, 3130/xl, 3500/xL and SeqStudio platforms | Spectrum Compact CE from Promega, 3130/xl, 3500/xL and SeqStudio platforms | Spectrum Compact CE from Promega, 3500/xL and SeqStudio platforms | Spectrum Compact CE from Promega, 3500/xL and SeqStudio platforms | Spectrum Compact CE from Promega, 3500/xL and SeqStudio platforms |
Spectrum Compact CE from Promega, 3500/xL and SeqStudio platforms |
Compatibility
AneuQuick™ Extra Plus v2.2 is optimized for 6-dye fragment analysis and is compatible with the following capillary electrophoresis platforms:
- Applied Biosystems™ 3500 Genetic Analyzer
- Applied Biosystems™ 3500xL Genetic Analyzer
- Applied Biosystems™ SeqStudio Genetic Analyzer
- Promega Spectrum Compact CE System
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