AZFcheck™ Kit v3.2

Description

AZFcheck™ Kit v3.2 is a molecular detection kit to check possible microdeletions on the male Y chromosome. Microdeletion in the azoospermia factor region (AZF) is known as the most common chromosomal structural abnormalities and is one of the main causes of infertility in men.

Infertility is one of the problems that has become very common nowadays and has attracted the attention of couples. This disease affects 15-20% of couples of reproductive ages worldwide, male infertility is included in about 20-30% of these cases and among them 5-10% is related to Y chromosome microdeletion. Using the AZFcheck™ v3.2 kit can help IVF clinics to diagnose the cause of infertility in the shortest possible time.

Assisted reproductive techniques (ART) such as intracytoplasmic sperm injection (ICSI) or testicular biopsy (TESE) can overcome the obstacles of natural conception and help some infertile couples reproduce. However, these methods increase the risk of passing genetic defects, including passing on AZF microdeletions and associated infertility problems, to their sons. Therefore, screening for AZF microdeletions before treatment with ART or other techniques is an important and critical diagnostic test that allows accurate results in the shortest possible time.

This diagnostic kit is based on 19 markers, including 16 STS markers (short DNA sequences of 300 to 500 base pairs that occur once in the genome), 2 SD markers (sex determination) and one STR marker (short repetitive sequences of 3 to 7 base pair) with high heterozygosity on the AZF gene.

It should be noted that this kit can diagnose Klinefelter syndrome, which is another cause of male infertility. However, it is recommended to use the AZFcheck™ Plus Kit v2.2 to diagnose Klinefelter syndrome.