Key Features & Benefits

• Rapid detection of aneuploidies involving chromosomes 13, 18, 21, X, and Y
• Based on Quantitative Fluorescent PCR (QF-PCR) technology
• Simultaneous amplification of 33 genetic markers in a single-tube multiplex PCR reaction
• Expanded chromosome coverage to improve confidence in result interpretation
• Incorporates Segmental Duplication (SD) markers to confirm STR findings and improve the detection of Turner syndrome
• Includes the unique DX-TATC 13.3 marker, which is not available in many commercially available QF-PCR kits
• Compatible with a broad range of prenatal and clinical DNA sample types
• Optimized for 6-dye fragment analysis
• Suitable for molecular genetics, prenatal diagnosis, and research laboratories

Delivers highly reliable and reproducible performance with minimal hands-on time

AneuQuick™ Extra v2.2 includes 33 genetic markers strategically distributed across chromosomes 13, 18, 21, X, and Y. The marker panel combines highly informative STR markers with Segmental Duplication (SD) markers, providing enhanced confidence in aneuploidy detection and improving the assessment of Turner syndrome.

Figure 1. Distribution of AneuQuick™ Extra v2.2 markers with the KBC600™ Size Standard.

In addition to STR markers, the kit incorporates eight Segmental Duplication markers (7/X, 11/X, 18/X, 21/2, 13/11, 18/1, 6/21, and 10/18). These markers serve as an independent confirmation of chromosome copy number abnormalities, helping reduce interpretation errors and increasing diagnostic confidence.

The panel also includes the proprietary DX-TATC 13.3 marker located on the short arm of chromosome X. This marker is absent from many comparable commercial assays and provides additional discriminatory power for chromosome X analysis.

The AneuQuick™ product family has been developed to provide flexible QF-PCR solutions for rapid prenatal aneuploidy testing. From routine screening to expanded chromosome coverage and combined SMA detection, the portfolio offers multiple assay configurations to meet the needs of different molecular genetics laboratories.

The comparison table below highlights the key specifications of each AneuQuick™ kit, including marker count, chromosome coverage, Segmental Duplication markers, SMA detection capability, dye chemistry, single-tube multiplex design, and compatibility with capillary electrophoresis platforms, making it easier to select the most appropriate solution for your laboratory workflow.

AneuQuick™ Extra v2.2 is optimized for 6-dye fragment analysis and is compatible with the following capillary electrophoresis platforms:

• Applied Biosystems™ 3500 Genetic Analyzer
• Applied Biosystems™ 3500xL Genetic Analyzer
• Applied Biosystems™ SeqStudio Genetic Analyzer
• Promega Spectrum Compact CE System