F9 SegCheck Kit v1.2

Hemophilia B Overview

Hemophilia B, also known as Christmas disease, is an X-linked recessive hereditary disorder predominantly affecting males. It is characterized by a deficiency in coagulation factor IX, leading to prolonged bleeding times. Patients with hemophilia B experience repeated episodes of bleeding, sometimes severe enough to cause disability or life-threatening situations ². Hemophilia B occurs at a rate of approximately 1 in 30,000 live male births. Currently, there are no effective treatments for hemophilia B, highlighting the importance of genetic counseling and prenatal diagnosis to manage this condition effectively ².

The pathogenic gene for hemophilia B is the F9 gene, located on the X chromosome. Mutations in this gene affect the production of factor IX, crucial for blood coagulation. Gene and prenatal diagnosis can be crucial for families with a history of hemophilia B, as identifying carriers and affected individuals early on can guide management and preventive measures ². The F9 SegCheck™ Kit v1.2, play a vital role in rapidly diagnosing hemophilia B and related chromosomal disorders, providing essential information for patient management and family planning.