{"id":7468,"date":"2026-07-13T14:50:50","date_gmt":"2026-07-13T11:20:50","guid":{"rendered":"https:\/\/kawsarbiotech.com\/product\/hba-gap-extra-kit\/"},"modified":"2026-09-26T00:27:21","modified_gmt":"2026-09-25T20:57:21","slug":"hba-gap-extra-kit","status":"publish","type":"product","link":"https:\/\/kawsarbiotech.com\/en\/product\/hba-gap-extra-kit\/","title":{"rendered":"HBA Gap Extra Kit"},"content":{"rendered":"<p style=\"text-align: left;\"><strong>HBA Gap Extra Kit \u2013 Detection of Common Alpha-Globin Gene Deletions<\/strong><\/p>\n<p style=\"text-align: left;\">HBA Gap Extra Kit is a molecular diagnostic kit based on <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5100720\/\" target=\"_blank\" rel=\"noopener\">Gap-PCR,<\/a> designed to aid in the detection of common alpha-globin gene deletions associated with <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1435\/\" target=\"_blank\" rel=\"noopener\">alpha-thalassemia<\/a>. Alpha-globin gene disorders can lead to different clinical conditions, ranging from mild forms of anemia to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20008179\/\" target=\"_blank\" rel=\"noopener\">HbH disease<\/a> and severe forms such as hydrops fetalis. These disorders are particularly prevalent in Southeast Asia, the Middle East, and Mediterranean populations.<\/p>\n<p style=\"text-align: left;\">The kit enables the detection of common alpha-globin gene deletions, including \u2212\u03b13.7, \u2212\u03b14.2, \u2212\u2212MED, and \u2212\u221220.5 kb, as well as alpha-globin 3.7 triplication (anti-3.7) and even quadruplication. Detection of these alterations can be particularly useful in the molecular investigation of alpha-thalassemia and in distinguishing alpha-thalassemia from beta-thalassemia in relevant screening settings.<\/p>\n<p style=\"text-align: left;\">PCR products are analyzed using agarose gel electrophoresis. To facilitate result interpretation, the kit includes an HBA Gap Extra <a href=\"https:\/\/kawsarbiotech.com\/en\/?s=allelic+ladder+&amp;post_type=product\">Allelic Ladder<\/a> containing reference fragments for the normal alpha-globin gene, common deletions (3.7 kb, 4.2 kb, 20.5 kb, and MED), and anti-3.7 triplication, allowing direct comparison with unknown samples.<\/p>\n<p style=\"text-align: left;\">HBA Gap Extra Kit provides a straightforward agarose gel-based approach for the molecular detection of common alpha-globin gene deletions and copy-number alterations associated with alpha-thalassemia.<\/p>\n<p style=\"text-align: left;\">HBA Gap Extra Kit is a Gap-PCR kit for detecting common alpha-globin gene deletions, including 3.7 kb, 4.2 kb, 20.5 kb and MED, as well as alpha-globin 3.7 triplication, using agarose gel electrophoresis<\/p>\n<p style=\"text-align: left;\">\n","protected":false},"excerpt":{"rendered":"<p>HBA Gap Extra Kit \u2013 Detection of Common Alpha-Globin Gene Deletions HBA Gap Extra Kit is a molecular diagnostic kit<\/p>\n","protected":false},"featured_media":7457,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[107,116],"product_tag":[],"class_list":["post-7468","product","type-product","status-publish","has-post-thumbnail","product_cat-diagnostic-kits-en","product_cat-mutation-detection-en","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/product\/7468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/comments?post=7468"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/media\/7457"}],"wp:attachment":[{"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/media?parent=7468"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/product_brand?post=7468"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/product_cat?post=7468"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/kawsarbiotech.com\/en\/wp-json\/wp\/v2\/product_tag?post=7468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}