کیت های MLPA

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SALSA MLPA kits for copy number quantification

MLPA® is the  leading method for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be used to determine if a known mutation is present in the DNA or to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and exclusive manufacturer of MLPA assays, offers more than 400 different MLPA panels used for DNA copy number quantification, mutation identification, and DNA methylation status.

(Popular MLPA (www.mlpa.com

Predisposition to Cancer
BRCA1, BRCA2,MLH1, MSH2, MSH6,PMS2,APC,MMR, NF1


Neuromuscular Disorders

SMA , DMD, CMT1
Intellectual Disability

microdeletion , PWS/AS, FMR1/AFF2 , MECP2 , Sotos , WBS , SHOX , aneuploidy

Solid Tumours
Gliomas , MMR , Neuroblastoma , TP53 , Breast 

Methylation profiling

Prader-Willi / Angelman syndrome , Fragile X , Beckwith-Wiedemann 

Advantages and features of MLPA
Examine up to 60 targets per reaction
Only 50ng of DNA is required per reaction
MLPA detects a short sequence of 60-80 nucleotides
Detection of single exon deletions and duplications
Detection of targeted point mutations
One simple protocol for  >400 applications
Results available within 24 hours
Limited lab equipment required: only a thermocycler and a sequence type electrophoresis system
User-friendly, reliable, and free data analysis software, Coffalser.NetTM
Visit the MLPA website www.mlpa.com to
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